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Flumethasone Pivalate

产品号 DB00663 公司名称 DrugBank
CAS号 2002-29-1 公司网站 http://www.ualberta.ca/
分子式 C27H36F2O6 电 话 (780) 492-3111
分子量 494.5679464 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 545

产品价格信息

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产品别名

标题
Flumethasone Pivalate
IUPAC标准名
2-[(1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl]-2-oxoethyl 2,2-dimethylpropanoate
IUPAC传统名
flumethasone pivalate
商标名
Locorten

产品登记号

CAS号 2002-29-1
PubChem CID 443980
PubChem SID 46505121

产品性质

疏水性(logP) 2.1
溶解度 0.392 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.
Indication For the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions
Pharmacology Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.
Toxicity Can lead to signs of irritation such as burning sensation, itching or skin rash at the site of application; hypersensitivity reactions.
Affected Organisms
Humans and other mammals
Biotransformation Primarily hepatic
Absorption Minimal if applied topically

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