Nystatin

• 产品号: DB00646
• CAS号: 1400-61-9
• 分子式: C47H75NO17
• 分子量: 926.0949

产品别名

• 标题: Nystatin
• IUPAC标准名: (21E,23E,25E,27E,31E,33E)-20-{[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxo-1-oxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid
• IUPAC传统名: nystatin
• 商标名: Nystatin-Triamcinolone Acetonide; Pedi-Dri; Nystex; Nysert; Barstatin 100; Candex; Korostatin; Mycolog-Ii; Mycostatin; Mykacet; Nadostine; Nilstat; Nyaderm; PMS Nystatin; Sodium nystatin; nystatin dihydrate; Myco-Triacet Ii; Mykinac; Mytrex F; Nystaform; Nystatin sodium; Nystatin, sodium salt; Nystop

产品登记号

• PubChem CID: 11953884
• PubChem SID: 46504780
• CAS号: 1400-61-9

产品性质

• 疏水性(logP): 0.5
• 溶解度: 360 mg/L

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: Nystatin is a polyene antifungal drug to which many molds and yeasts are sensitive, including Candida spp. Nystatin has some toxicity associated with it when given intravenously, but it is not absorbed across intact skin or mucous membranes. It is considered a relatively safe drug for treating oral or gastrointestinal fungal infections.
• Indication: For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
• Pharmacology: Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.
• Affected Organisms: Fungi
• Absorption: Nystatin is not absorbed from intact skin or mucous membrane.
• References: Akaike N, Harata N: Nystatin perforated patch recording and its applications to analyses of intracellular mechanisms. Jpn J Physiol. 1994;44(5):433-73. [Pubmed]
• External Links: Wikipedia; RxList; PDRhealth; Drugs.com

参考文献

• Akaike N, Harata N: Nystatin perforated patch recording and its applications to analyses of intracellular mechanisms. Jpn J Physiol. 1994;44(5):433-73. Pubmed