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Dyclonine

产品号 DB00645 公司名称 DrugBank
CAS号 586-60-7 公司网站 http://www.ualberta.ca/
分子式 C18H27NO2 电 话 (780) 492-3111
分子量 289.41248 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 527

产品价格信息

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产品别名

标题
Dyclonine
IUPAC标准名
1-(4-butoxyphenyl)-3-(piperidin-1-yl)propan-1-one
IUPAC传统名
dyclonine
商标名
Tanaclone
Dyclocaine
Dyclonine HCL
Dycloninum [INN-Latin]
Dyclonine hydrochloride
Diclonina [INN-Spanish]
Diclonia
Diclonina
Dyclocainum
Dyclone
Dyclonin
Dyclothane

产品登记号

PubChem SID 46506697
CAS号 586-60-7
PubChem CID 3180

产品性质

疏水性(logP) 3.7
溶解度 Soluble (HCl salt)

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray.
Indication Used to provide topical anesthesia of accessible mucous membranes prior to examination, endoscopy or instrumentation, or other procedures involving the esophagus, larynx, mouth, pharynx or throat, respiratory tract or trachea, urinary tract, or vagina. Also used to suppress the gag reflex and/or other laryngeal and esophageal reflexes to facilitate dental examination or procedures (including oral surgery), endoscopy, or intubation. Also used for relief of canker sores, cold sores or fever blister.
Pharmacology Dyclonine is an oral anasthetic. If substantial quantities of local anesthetics are absorbed through the mucosa, actions on the central nervous system (CNS) may cause CNS stimulation and/or CNS depression. Actions on the cardiovascular system may cause depression of cardiac conduction and excitability and, with some of these agents, peripheral vasodilation.
Toxicity Symptoms of overdose include cardiovascular system depression, CNS toxicity, and methemoglobinemia.
Affected Organisms
Humans and other mammals
Absorption Readily absorbed through mucous membranes into the systemic circulation. The rate of absorption is influenced by the vascularity or rate of blood flow at the site of application, the total dosage (concentration and volume) administered, and the duration of exposure. Absorption from mucous membranes of the throat or respiratory tract may be especially rapid.
Half Life Approximately 30 to 60 minutes.
External Links
Wikipedia
Drugs.com

参考文献