Sulfacetamide

• 产品号: DB00634
• CAS号: 144-80-9
• 分子式: C8H10N2O3S
• 分子量: 214.2416

产品别名

• 标题: Sulfacetamide
• IUPAC标准名: N-(4-aminobenzenesulfonyl)acetamide
• IUPAC传统名: N-(4-aminobenzenesulfonyl)acetamide
• 商标名: P-Aminobenzenesulfonoacetamide; Acetosulfamine; Steri-Units Sulfacetamide; Albucid; Sebizon; Bleph-10; Formosulfacetamide; Isopto Cetamide; N-Acetylsulfanilamide; N-Acetylsulfanilamine; Oclucid; P-Aminobenzenesulfonacetamide; Sulamyd; Sulfacet; Sulfacetamide Sodium; Urosulfon; Acetosulfamin; Albamine; Alesten; Gyne-Sulf; Klaron; N-Sulfanilylacetamide; N-Sulphanilylacetamide; Ocusulf-10; Op-Sulfa 30; Ophthacet; Ophthel-S; Region; Sodium Sulfacetamide; Steramide; Sulf-15; Sulfacyl; Sulfair; Sulfair 10; Sulfair 15; Sulfamide; Sulfanilacetamide; Sulfex; Sulphacetamide Sodium; Trysul; Acetocid; Ak-Sulf; Bleph-10 Liquifilm; Cetamide; I-Sulfacet; Isopto-Cetamide; N'-Acetylsulfanilamide; Sodium Sulamyd; Sulf-10; Sulfacel-15; Sulfacetamide Sodium Anhydrous; Sulfacetamide Sodium Usp; Sulfacetimide; Sulfair Forte; Sulfair-15; Sulfanilazetamid; Sulphacetamide; Sulphasil; Sulten-10; Sultrin; Urosulfone

产品登记号

• CAS号: 144-80-9
• PubChem SID: 46504544
• PubChem CID: 5320

产品性质

• 疏水性(logP): -0.6
• 溶解度: 1.25E+004 mg/L

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: An anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections. [PubChem]
• Indication: For the treatment of bacterial vaginitis, keratitis, acute conjunctivitis, and blepharitis.
• Pharmacology: Sulfacetamide is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
• Toxicity: Oral LD₅₀ Mouse : 16500 mg/kg. Side effects include moderate to severe erythema (redness) and moderate edema (raised kin), nausea, vomiting, headache, dizziness, and tiredness. Higher exposure causes unconsciousness.
• Affected Organisms: Enteric bacteria and other eubacteria
• Half Life: 7-12.8 hours
• References: Hull CA, Johnson SM: A double-blind comparative study of sodium sulfacetamide lotion 10% versus selenium sulfide lotion 2.5% in the treatment of pityriasis (tinea) versicolor. Cutis. 2004 Jun;73(6):425-9. [Pubmed] ; Del Rosso JQ: Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations. Cutis. 2004 Jan;73(1 Suppl):29-33. [Pubmed] ; Roth HW, Leimbeck R, Sonnenschein B, Anger CB, Weber S: [The effective antibacterial spectrum of sulfacetamide] Klin Monatsbl Augenheilkd. 1992 Mar;200(3):182-6. [Pubmed]
• External Links: Wikipedia; RxList; PDRhealth; Drugs.com

参考文献

• Hull CA, Johnson SM: A double-blind comparative study of sodium sulfacetamide lotion 10% versus selenium sulfide lotion 2.5% in the treatment of pityriasis (tinea) versicolor. Cutis. 2004 Jun;73(6):425-9. Pubmed
• Del Rosso JQ: Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations. Cutis. 2004 Jan;73(1 Suppl):29-33. Pubmed
• Roth HW, Leimbeck R, Sonnenschein B, Anger CB, Weber S: [The effective antibacterial spectrum of sulfacetamide] Klin Monatsbl Augenheilkd. 1992 Mar;200(3):182-6. Pubmed