| Item |
Information |
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Drug Groups
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approved; investigational |
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Description
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A synthetic hormone with anabolic and androgenic properties. [PubChem] |
| Indication |
Use to promote weight gain after weight loss following extensive surgery. |
| Pharmacology |
Oxandrolone is an anabolic steroids indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight, to offset the protein catabolism associated with prolonged administration of corticosteroids, and for the relief of the bone pain frequently accompanying osteoporosis. Anabolic steroids are synthetic derivatives of testosterone. |
| Toxicity |
The oral LD50 of oxandrolone in mice and dogs is greater than 5,000 mg/kg. |
| Affected Organisms |
| • |
Humans and other mammals |
|
| Biotransformation |
Renal |
| Half Life |
0.55 hours (1st phage), 9 hours (2nd phase) |
| References |
| • |
Demling RH, DeSanti L: Oxandrolone induced lean mass gain during recovery from severe burns is maintained after discontinuation of the anabolic steroid. Burns. 2003 Dec;29(8):793-7.
[Pubmed]
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| External Links |
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