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Fluticasone Propionate

产品号 DB00588 公司名称 DrugBank
CAS号 80474-14-2 公司网站 http://www.ualberta.ca/
分子式 C25H31F3O5S 电 话 (780) 492-3111
分子量 500.5708496 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 470

产品价格信息

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产品别名

标题
Fluticasone Propionate
IUPAC标准名
(1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14-{[(fluoromethyl)sulfanyl]carbonyl}-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl propanoate
IUPAC传统名
fluticasone propionate
商标名
Flovent
Flunase
Flovent Diskus 100
Advair Diskus 250/50
Advair Diskus 100/50
Advair Diskus 500/50
Cutivate
Flixonase
Flixotide
Flonase
Flovent Diskus 250
Flovent Diskus 50
Flovent HFA
Advair Diskus
别名
fluticasone propionate

产品登记号

PubChem SID 46506140
CAS号 80474-14-2
PubChem CID 444036

产品性质

疏水性(logP) 3.4
溶解度 0.51 mg/L (insoluble)

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; investigational
Description Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma.
Indication For the maintenance treatment of asthma as prophylactic therapy and for patients requiring oral corticosteroid therapy for asthma.
Pharmacology Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma.
Affected Organisms
Humans and other mammals
Biotransformation Fluticasone propionate is metabolized in the liver by cytochrome P450 3A4-mediated hydrolysis of the 5-fluoromethyl carbothioate grouping. This transformation occurs in 1 metabolic step to produce the inactive 17-(beta)-carboxylic acid metabolite, the only known metabolite detected in man.
Absorption The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier.
Half Life 10 hours
Protein Binding 91%
Distribution * 2.3 to 16.7 L/kg
Clearance * 1093 mL/min
External Links
RxList
Drugs.com

参考文献