Udenafil

• 产品号: DB06267
• CAS号: 268203-93-6
• 分子式: C25H36N6O4S
• 分子量: 516.65614

产品别名

• 标题: Udenafil
• IUPAC标准名: 3-{1-methyl-7-oxo-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-5-yl}-N-[2-(1-methylpyrrolidin-2-yl)ethyl]-4-propoxybenzene-1-sulfonamide
• IUPAC传统名: @udenafil
• 商标名: Zydena

产品登记号

• CAS号: 268203-93-6
• PubChem SID: 99443240
• PubChem CID: 6918523

产品详细信息

详细说明 (English)

• Drug Groups: approved; investigational
• Description: Udenafil is a new phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It has been approved in South Korea and will be marketed under the brand name Zydena. It is not yet approved for use in the U.S., E.U., or Canada.
• Indication: Investigated for use/treatment in erectile dysfunction and hypertension.
• Pharmacology: Udenafil is a potent selective phosphodiesterase type 5 (PDE5) inhibitor.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic. Metabolized by CYP3A4 and CYP3A5.
• References: Ji HY, Shim HJ, Yoo M, Park ES, Lee HS: Transport of a new erectogenic udenafil in Caco-2 cells. Arch Pharm Res. 2007 Sep;30(9):1168-73. [Pubmed] ; Ku HY, Ahn HJ, Seo KA, Kim H, Oh M, Bae SK, Shin JG, Shon JH, Liu KH: The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil. Drug Metab Dispos. 2008 Jun;36(6):986-90. Epub 2008 Feb 28. [Pubmed]
• External Links: Wikipedia

参考文献

• Ji HY, Shim HJ, Yoo M, Park ES, Lee HS: Transport of a new erectogenic udenafil in Caco-2 cells. Arch Pharm Res. 2007 Sep;30(9):1168-73. Pubmed
• Ku HY, Ahn HJ, Seo KA, Kim H, Oh M, Bae SK, Shin JG, Shon JH, Liu KH: The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil. Drug Metab Dispos. 2008 Jun;36(6):986-90. Epub 2008 Feb 28. Pubmed