Permethrin

• 产品号: DB04930
• CAS号: 52645-53-1
• 分子式: C21H20Cl2O3
• 分子量: 391.2877

产品别名

• 标题: Permethrin
• IUPAC标准名: (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate
• IUPAC传统名: permethrin
• 商标名: Elimite; Nix Cream Rinse; Elimite Cream; PerFoam; Acticin Cream; Nix
• 别名: permethrin

产品登记号

• PubChem SID: 46505374
• CAS号: 52645-53-1
• PubChem CID: 40326

产品性质

• 疏水性(logP): 6.50 [HANSCH,C ET AL. (1995)]
• 溶解度: 6e-06 mg/mL at 20 oC [USDA PESTICIDE PROP DATABASE]

产品详细信息

详细说明 (English)

• Drug Groups: approved; investigational
• Description: A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.
• Indication: For the treatment of infestation with Sarcoptes scabiei (scabies).
• Pharmacology: Permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods.
• Toxicity: Oral, rat LD₅₀: 430 - 4000 mg/kg; skin, rabbit LD₅₀: 2000 mg/kg.
• Affected Organisms: Scabies (Sarcoptes scabei) and other insects
• Biotransformation: Rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.
• Absorption: Poorly absorbed through the skin.
• Elimination: Permethrin is rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.
• References: Abedin S, Narang M, Gandhi V, Narang S: Efficacy of permethrin cream and oral ivermectin in treatment of scabies. Indian J Pediatr. 2007 Oct;74(10):915-6. [Pubmed]
• External Links: Wikipedia; RxList; Drugs.com

参考文献

• Abedin S, Narang M, Gandhi V, Narang S: Efficacy of permethrin cream and oral ivermectin in treatment of scabies. Indian J Pediatr. 2007 Oct;74(10):915-6. Pubmed