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Vinblastine

产品号 DB00570 公司名称 DrugBank
CAS号 865-21-4 公司网站 http://www.ualberta.ca/
分子式 C46H58N4O9 电 话 (780) 492-3111
分子量 810.97412 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 452

产品价格信息

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产品别名

标题
Vinblastine
IUPAC标准名
methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraene-10-carboxylate
IUPAC传统名
vincaleukoblastine
商标名
Vinblastin
Velbe
Vincoblastine
Vinblastina [Dcit]
Vincaleucoblastin
Vinblastinum [INN-Latin]
Nincaluicolflastine
Rozevin
Velban
Vinblastine Sulfate
Vincaleucoblastine
Vincaleukoblastine

产品登记号

PubChem SID 46504550
CAS号 865-21-4
PubChem CID 241903

产品性质

疏水性(logP) 3.9
溶解度 Negligible

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Indication For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
Pharmacology Vinblastine is a vinca alkaloid antineoplastic agent. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units: vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinblastine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Toxicity Oral, mouse: LD50 = 423 mg/kg; Oral, rat: LD50 = 305 mg/kg.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic. Metabolism of vinblastine has been shown to be mediated by hepatic cytochrome P450 3A isoenzymes.
Half Life Triphasic: 35 min, 53 min, and 19 hours
Protein Binding 98-99%
Elimination The major route of excretion may be through the biliary system.
References
Starling D: Two ultrastructurally distinct tubulin paracrystals induced in sea-urchin eggs by vinblastine sulphate. J Cell Sci. 1976 Jan;20(1):79-89. [Pubmed]
External Links
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参考文献

  • Starling D: Two ultrastructurally distinct tubulin paracrystals induced in sea-urchin eggs by vinblastine sulphate. J Cell Sci. 1976 Jan;20(1):79-89. Pubmed