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Methaqualone

产品号 DB04833 公司名称 DrugBank
CAS号 72-44-6 公司网站 http://www.ualberta.ca/
分子式 C16H14N2O 电 话 (780) 492-3111
分子量 250.29516 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 4377

产品价格信息

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产品别名

标题
Methaqualone
IUPAC标准名
2-methyl-3-(2-methylphenyl)-3,4-dihydroquinazolin-4-one
IUPAC传统名
methaqualone
商标名
Roulone
Nethaqualone
Methaqualoneinone
Metakvalon
TR 495 monohydrochloride
Fadormir
Hyptor
Mequin
Optinoxan
Sindesvel
Somberol
Somnomed
Dormigoa-schlafmittel
Holodorm
Hypocol
Ipnofil
Melsed
Methaqualon
Metolquizolone
Motolon
Mozambin
Optimil
QZ 2 hydrochloride
Quaalude hydrochloride
Revonal
Rorer 148
Rorer 714
Sopor hydrochloride
Torinal
Tuazolone
Aqual
Cateudyl
Citexal
Dormigoa
Dormogen
Dorsedin
Hyminal
Hyminal monohydrochloride
Hypcol
Hyptor base
Melsed HCL
Melsedin
Melsomin
Mequal
Metaqualon
Methachalonum
Methased
Mollinox
Nobedorm
Noctilene
Normi-nox
Omnyl
Parest
Parminal
Pro-dorm
Quaalude
Rouqualone
Somnafac
Somnofac
Sonal
Sopor
Tuazol
Tuazole
Dormutil
Orthonal
Ortonal
Soverin
别名
Methyl-o-tolylquinazolone
MAOA
Methaqualonum [inn-latin]
Methylquinazolone hydrochloride
MTQ
2-Methyl-3-(o-tolyl)-4(3H)-quinazolinone hydrochloride
2-Methyl-3-(2-methylphenyl)-4-quinazolinone
2-Methyl-3-o-tolyl-4-quinazolone
Metachalon [czech]
Metacualona [inn-spanish]
Methaqualone hydrochloride
2-Methyl-3-o-tolyl-4(3H)-chinazolinon [German]
2-Methyl-3-o-tolyl-4 (3H)-chinazolinon
2-Methyl-3-o-tolyl-3H-quinazolin-4-one
2-Methyl-3-(o-tolyl)-4-quinazolone hydrochloride
2-Methyl-3-(o-tolyl)-3,4-dihydro-4-quinazolinone
2-Methyl-3-(2-tolyl)quinazol-4-one
2-Methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
3,4-Dihydro-2-methyl-4-oxo-3-o-tolylquinazoline
2-Methyl-3-tolylchinazolon-4 hydrochloride
2-Methyl-3-o-tolyl-4(3H)-quinazolinone
2-Methyl-3-o-tolyl-4(3H)-chinazolone
Diamthazole dihydrochloride
Metaqualone [dcit]
2-Methyl-3-tolyl-4-oxybensdiazine
MTQ hydrochloride

产品登记号

PubChem CID 6292
CAS号 72-44-6
PubChem SID 46507178

产品性质

产品详细信息

详细说明 (English)
Item Information
Drug Groups illicit; withdrawn
Description Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative-hypnotic activity was first noted by Indian researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan. Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a sedative and muscle relaxant. It has also been used illegally as a recreational drug, commonly known as Quaaludes, Sopors, Ludes or Mandrax (particularly in the 1970s in North America) depending on the manufacturer. Since at least 2001, it has been widely used in South Africa, where it is commonly referred to as "smarties" or "geluk-tablette" (meaning happy tablets). Clandestinely produced methaqualone is still seized by government agencies and police forces around the world. [Wikipedia]
Indication For the treatment of insomnia, and as a sedative and muscle relaxant.
Toxicity Symptoms of overdose include delirium, convulsions, muscle spasms or seizure, cardiac arrest, shortness or loss of breath, vomiting or nausea, and coma or death. The LD50 for mice is 1250 mg/kg and for rats is 326 mg/kg (Strasenburg Labs).
Affected Organisms
Humans and other mammals
References
Potential Analgesics. Part I. Synthesis of substituted 4-quinazolones, I. K. Kacker and S. H. Zaheer, J. Ind. Chem. Soc. 28 (1951), pp. 344–346.
External Links
Wikipedia

参考文献

  • Potential Analgesics. Part I. Synthesis of substituted 4-quinazolones, I. K. Kacker and S. H. Zaheer, J. Ind. Chem. Soc. 28 (1951), pp. 344–346.