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Cephalexin

产品号 DB00567 公司名称 DrugBank
CAS号 15686-71-2 公司网站 http://www.ualberta.ca/
分子式 C16H17N3O4S 电 话 (780) 492-3111
分子量 347.38888 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 449

产品价格信息

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产品别名

标题
Cephalexin
IUPAC标准名
(6R,7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
IUPAC传统名
cephalexin
商标名
Inphalex
Madlexin
Cefax
Cepexin
Keflet
Biocef
Cefadin
Cefaleksin
Cepastar
Cephacillin
Cephin
Keftab
Mamlexin
Sporidex
Uphalexin
Alexin
Cephaxin
Ceporexin
Check
Ed A-Ceph
Erocetin
Ibrexin
Kidolex
Larixin
Lenocef
Lopilexin
Mamalexin
Medoxine
Nufex
Pyassan
Sanaxin
Sepexin
Servispor
Sporicef
Syncl
Syncle
Voxxim
Alcephin
Alsporin
Cefa-iskia
Cefablan
Cefadal
Cefadina
Cefaseptin
Ceforal
Cefovit
Cephanasten
Cepol
Ceporex Forte
Ceporexin-E
Ceporexine
Cophalexin
Durantel
Durantel DS
Factagard
Felexin
Fexin
Ibilex
Kefalospes
Keflex
Kefolan
Kekrinal
Lafarine
Lexibiotico
Neolexina
Novolexin
Oriphex
Ortisporina
Ospexin
Palitrex
Panixine Disperdose
Pectril
Sartosona
Sencephalin
Sinthecillin
Tepaxin
Winlex
Carnosporin
Cefalin
Cefaloto
Celexin
Ceporex
Keforal
L-Keflex
Lonflex
Neokef
Oracef
Oroxin
Roceph
Sialexin
Synecl
Tokiolexin
Zozarine
别名
Cefalexinum [INN-Latin]
Cefalexina [INN-Spanish]
Cephalexin hydrate
Cefalexine [INN-French]
Cefalessina [DCIT]
Cefalexin Sodium
Cefalexin
Cephalexin 1-hydrate
Cephalexin monohydrate
Cephalexine
CEX
Cephalexinum

产品登记号

PubChem CID 27447
CAS号 15686-71-2
PubChem SID 46506749

产品性质

疏水性(logP) 0
溶解度 1789 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of cephaloridine or cephalothin, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. [PubChem]
Indication For the treatment of respiratory tract infections caused by Streptococcus pneumoniae and Streptococcus pyogenes; otitis media due to Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Moraxella catarrhalis; skin and skin structure infections caused by Staphylococcus aureus and/or Streptococcus pyogenes; bone infections caused by Staphylococcus aureus and/or Proteus mirabilis; genitourinary tract infections, including acute prostatitis, caused by Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae.
Pharmacology Cephalexin (also called Cefalexin) is a first generation cephalosporin antibiotic. It is one of the most widely prescribed antibiotics, often used for the treatment of superficial infections that result as complications of minor wounds or lacerations. It is effective against most gram-positive bacteria.
Toxicity Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting. The oral median lethal dose of cephalexin in rats is >5000 mg/kg.
Affected Organisms
Enteric bacteria and other eubacteria
Biotransformation No appreciable biotransformation in the liver (90% of the drug is excreted unchanged in the urine).
Absorption Well absorbed from the gastrointestinal tract
Half Life 1 hour
Protein Binding 14%
Elimination Cephalexin is excreted in the urine by glomerular filtration and tubular secretion. Studies showed that over 90% of the drug was excreted unchanged in the urine within 8 hours.
External Links
Wikipedia
RxList
PDRhealth
Drugs.com

参考文献