Sitagliptin

• 产品号: Bio-0943
• CAS号: 486460-32-6
• 分子式: C16H15F6N5O
• 分子量: 407.3136192

产品别名

• 标题: Sitagliptin
• IUPAC标准名: (3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
• IUPAC传统名: (3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
• 别名: MK-0431

产品登记号

• CAS号: 486460-32-6

产品性质

• 应用领域: Antidiabetic drug
• 生物活性机理: Dipeptidyl peptidase-4 (DPP-4) inhibitor

参考文献

• Herman GA; Stevens C, Van Dyck K, Bergman A, Yi B, De Smet M, Snyder K, Hilliard D, Tanen M, Tanaka W, Wang AQ, Zeng W, Musson D, Winchell G, Davies MJ, Ramael S, Gottesdiener KM, Wagner JA.
• "Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind,
• placebo-controlled studies with single oral doses". Clin Pharmacol Ther 78 (6): 675?8. (December 2005)