Ivabradine hydrochloride

• 产品号: Bio-0939
• CAS号: 148849-67-6
• 分子式: C27H37ClN2O5
• 分子量: 505.04608

产品别名

• 标题: Ivabradine hydrochloride
• IUPAC标准名: 3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one hydrochloride
• IUPAC传统名: 3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one hydrochloride
• 别名: S-16257; Corlentor; Procoralan; Coralan

产品登记号

• CAS号: 148849-67-6

产品性质

• 应用领域: Used for the symptomatic management of stable angina pectoris.
• 成盐信息: HCl
• 生物活性机理: Selectively inhibits the pacemaker I(f) current in a dose-dependent manner.
• 生物活性机理: Blocking this channel reduces cardiac pacemaker activity, slowing the heart rate and allowing more time for blood to flow to the myocardium.

参考文献

• 1. Thollon C, Cambarrat C, Vian J, Prost JF, Peglion JL, Vilaine JP (1994). "Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations:
• comparison with UL-FS 49". Br. J. Pharmacol. 112 (1): 37?2.
• 2. Sulfi S, Timmis AD (2006). "Ivabradine -- the first selective sinus node I(f) channel inhibitor in the treatment of stable angina". Int. J. Clin. Pract. 60 (2): 222?.
• 3. Tardif JC, Ford I, Tendera M, Bourassa MG, Fox K (2005). "Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina".
• Eur. Heart J. 26 (23): 2529?6.