Natamycin

• 产品号: Bio-0933
• CAS号: 7681-93-8
• 分子式: C33H47NO13
• 分子量: 665.72518

产品别名

• 标题: Natamycin
• IUPAC标准名: (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-{[(2R,3S,4S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0^5,^7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
• IUPAC传统名: (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-{[(2R,3S,4S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0^5,^7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
• 别名: Myprozine; Natacyn; Pimafucin; Tennecetin; Mycophyt; Natafucin; Pimafugin; Synogil; Tymasil

产品登记号

• CAS号: 7681-93-8

产品性质

• 应用领域: Macrolide polyene antifungal antibiotic.
• 应用领域: Used to treat fungal keratitis.
• 生物活性机理: Binds to ergosterol in the plasma membrane, preventing ergosterol-dependent fusion of vacuoles, as well as membrane fusion and fission.

参考文献

• 1. te Welscher YM, Jones L, van Leeuwen MR, Dijksterhuis J, de Kruijff B, Eitzen G, Breukink E: Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol.
• Antimicrob Agents Chemother. 2010 Jun;54(6):2618-25. Epub 2010 Apr 12.
• 2. te Welscher YM, ten Napel HH, Balague MM, Souza CM, Riezman H, de Kruijff B, Breukink E: Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane.
• J Biol Chem. 2008 Mar 7;283(10):6393-401. Epub 2007 Dec 29.