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Zidovudine

产品号 Bio-0890 公司名称 InterBioScreen
CAS号 30516-87-1 公司网站 http://www.ibscreen.com
分子式 C10H13N5O4 电 话 +7 49652 40091
分子量 267.24132 传 真 +7 49652 40092
纯 度 电子邮件 screen@ibscreen.chg.ru
保 存 Chembase数据库ID: 119449

产品价格信息

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产品别名

标题
Zidovudine
IUPAC标准名
1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
IUPAC传统名
1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
别名
3'-Azido-3'-deoxythymidine
Retrovir
Apovir
3'-Azidothymidine
Novo-AZT
Zidovir

产品登记号

CAS号 30516-87-1

产品性质

应用领域 Antiviral agent active exclusively against retroviruses, esp. AIDS virus and leukaemias
应用领域 Drugs of choice for AIDS treatment
生物活性机理 Reverse Transcriptase Inhibitor
生物活性机理 Nucleoside transporter substrate

产品详细信息

参考文献

  • 1. Mitsuya H, Yarchoan R, Broder S: Molecular targets for AIDS therapy. Science. 1990 Sep 28;249(4976):1533-44.
  • 2. Mitsuya H, Weinhold KJ, Furman PA, St Clair MH, Lehrman SN, Gallo RC, Bolognesi D, Barry DW, Broder S: 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and
  • cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc Natl Acad Sci U S A. 1985 Oct;82(20):7096-100.
  • 3. Yarchoan R, Mitsuya H, Broder S: AIDS therapies. Sci Am. 1988 Oct;259(4):110-9.
  • 4. De Clercq E: HIV resistance to reverse transcriptase inhibitors. Biochem Pharmacol. 1994 Jan 20;47(2):155-69.
  • 5. Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O'Sullivan MJ, VanDyke R, Bey M, Shearer W, Jacobson RL, et al.: Reduction of maternal-infant transmission
  • of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med. 1994 Nov 3;331(18):1173-80.