lovastatin

• 产品号: Bio-0873
• CAS号: 75330-75-5
• 分子式: C24H36O5
• 分子量: 404.53964

产品别名

• 标题: lovastatin
• IUPAC标准名: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
• IUPAC传统名: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
• 别名: Mevinacor; Nergadan; Mevacor; Monacolin K; Tancor; Lipofren

产品登记号

• CAS号: 75330-75-5

产品性质

• 生物来源: Metab. of Aspergillus terreus and Monascus ruber
• 应用领域: Antihyperlipidaemic agent
• 生物活性机理: Inhibitor of cholesterol biosynthesis
• 生物活性机理: Potent inhibitor of HMG-CoA

参考文献

• Alberts et al (1980) Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc.Natl.Acad.Sci.USA 77 3957.