Cyclosporin A

• 产品号: Bio-0872
• CAS号: 59865-13-3
• 分子式: C62H111N11O12
• 分子量: 1202.61124

产品别名

• 标题: Cyclosporin A
• IUPAC标准名: (12R)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
• IUPAC传统名: (12R)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
• 别名: Sandimmun; Cyclosporine; Sandimmune; Neoral; Cyclorin; Ramihyphin A

产品登记号

• CAS号: 59865-13-3

产品性质

• 应用领域: Possesses antifungal activity and immunosuppressive props. with a specific action on T-lymphocytes
• 应用领域: Used clinically as an immunosuppressant after transplant surgery
• 生物来源: Metab. of Trichoderma inflatum (previously Trichoderma polysporum). Also isol. from Fusarium solani and Tolypocladium sinense
• 简要说明: Conformers
• 生物活性机理: Calcineurin inhibitor

参考文献

• Merck Index 12 2821. Fruman et al (1992) Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc.Natl.Acad.Sci.USA 89 3686.