Aminoglutethimide

• 产品号: Bio-0777
• CAS号: 125-84-8
• 分子式: C13H16N2O2
• 分子量: 232.27834

产品别名

• 标题: Aminoglutethimide
• IUPAC标准名: 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
• IUPAC传统名: 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
• 别名: Orimeten; Elipten; Cytadren

产品登记号

• CAS号: 125-84-8

产品性质

• 应用领域: Originally used as anticonvulsant, withdrawn due to adrenotoxicity.
• 应用领域: Now used as aromatase inhibitor for treatment of breast cancer in postmenopausal women and for treatment of secondary hyperaldosteronism and oedema
• 应用领域: Inhibits adrenal corticosteroid synthesis
• 生物活性机理: Aromatase inhibitor
• 生物活性机理: Mineralocorticoid synthesis inhibitor
• 生物活性机理: Inhibits hydroxylations required for aromatization of androgens to estrogens
• 生物活性机理: Corticosteroid synthesis inhibitor
• 生物活性机理: Cholesterol desmolase inhibitor
• 生物活性机理: Androgen synthesis inhibitor
• 生物活性机理: Corticosteroid antagonist

参考文献

• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 404A, (ir)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1456C, (nmr)
• Lee, C.M. et al., J.A.C.S., 1961, 83, 4586, (uv, ir)
• Ruecker, G. et al., Arch. Pharm. (Weinheim, Ger.), 1969, 302, 204, (ms)
• Defay, N. et al., J. Pharm. Belg., 1972, 27, 335, (pmr)
• Aboul-Enein, H.Y. et al., J. Med. Chem., 1975, 18, 736, (synth, pharmacol)
• Santen, R.J. et al., Pharmanual (Basel), Vol. 2: A Comprehensive Guide to the Therapeutic Use of Aminoglutethimide, Karger, Basel, Switz., 1981, (book)
• Salhanick, H.A., Cancer Res., 1982, 42, 3315, (pharmacol)
• Aboul-Enein, H.Y., Anal. Profiles Drug Subst., 1986, 15, 35, (rev)
• Van Roey, P. et al., Acta Cryst. C, 1991, 47, 829, (cryst struct, bibl)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 454
• Bushell, S.M. et al., Tetrahedron, 1998, 54, 2269-2274, (synth, ir, pmr, cmr)
• Chang, M.-Y. et al., Tet. Lett., 2000, 41, 10273-10276, (synth)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, AKC600