Albendazole

• 产品号: Bio-0773
• CAS号: 54965-21-8
• 分子式: C12H15N3O2S
• 分子量: 265.3314

产品别名

• 标题: Albendazole
• IUPAC标准名: methyl N-[5-(propylsulfanyl)-1H-1,3-benzodiazol-2-yl]carbamate
• IUPAC传统名: methyl N-[5-(propylsulfanyl)-1H-1,3-benzodiazol-2-yl]carbamate
• 别名: Zentel; Alben; Helmintal; Eskazole; Bermosol; Valbazen

产品登记号

• CAS号: 54965-21-8

产品性质

• 应用领域: Anthelmintic.
• 应用领域: Investigated for treatment of chronic stronglyoidiasis, and for microsporidiosis in AIDS patients
• 生物活性机理: Causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin,
• 生物活性机理: thus inhibiting its polymerization or assembly into microtubules.
• 生物活性机理: The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores.
• 生物活性机理: Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP),
• 生物活性机理: which is the energy required for the survival of the helminth.
• 生物活性机理: Due to diminished energy production, the parasite is immobilized and eventually dies

参考文献

• U.S. Pat., 1975, SmithKline, 3 915 986; CA, 84, 31074r, (synth, pharmacol)
• Theodorides, V.J. et al., Experientia, 1976, 32, 702, (pharmacol)
• Bogan, J.A., Drugs of Today (Barcelona), 1979, 15, 87, (rev)
• Gyurik, R.J. et al., Drug Metab. Dispos., 1981, 9, 503, (metab)
• Bochis, R.J. et al., J. Med. Chem., 1981, 24, 1518, (props)
• Firth, M., Int. Congr. Symp. Ser. R. Soc. Med., (Ed.), No. 61, 1984, (book)
• Delatour, P. et al., Xenobiotica, 1991, 21, 217, (metab)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 38
• Archibald, L.K. et al., Quart. J. Med., 1993, 86, 191, (use)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 2970, (synonyms)
• Oldfield, E.C., Am. J. Gastroenterol., 1995, 90, 159, (use)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, VAD000