Chlorprothixene

• 产品号: Bio-0770
• CAS号: 113-59-7
• 分子式: C18H18ClNS
• 分子量: 315.86022

产品别名

• 标题: Chlorprothixene
• IUPAC标准名: {3-[(9Z)-2-chloro-9H-thioxanthen-9-ylidene]propyl}dimethylamine
• IUPAC传统名: {3-[(9Z)-2-chloro-9H-thioxanthen-9-ylidene]propyl}dimethylamine
• 别名: Truxal; Tarasan; Chlothixen; Taractan; Traquilan

产品登记号

• CAS号: 113-59-7

产品性质

• 应用领域: Tranquilliser
• 应用领域: Neuroleptic
• 应用领域: Psychosedative
• 应用领域: Antihistamine
• 生物活性机理: Strong blocking effects at the following postsynaptic receptors:
• 生物活性机理: 5-HT2 : anxiolysis, antipsychotic effects
• 生物活性机理: D1, D2, D3 : antipsychotic effects
• 生物活性机理: H1 : sedation, weight gain
• 生物活性机理: Muscarinic : anticholinergic side effects, extrapyramidal side effects attenuated
• 生物活性机理: Alpha1 : hypotension, tachycardia

参考文献

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• Post, M.L. et al., Acta Cryst. B, 1974, 30, 1644, (cryst struct)
• Kaiser, C. et al., J. Med. Chem., 1974, 17, 131, (pmr)
• Irwin, W.J. et al., Chem. Br., 1982, 708, (hplc)
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• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 581
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, TAF675