您当前所在的位置:首页 > 产品中心 > 产品信息
Piroxicam_分子结构_CAS_36322-90-4)
点击图片或这里关闭

Piroxicam

产品号 Bio-0759 公司名称 InterBioScreen
CAS号 36322-90-4 公司网站 http://www.ibscreen.com
分子式 C15H13N3O4S 电 话 +7 49652 40091
分子量 331.34642 传 真 +7 49652 40092
纯 度 电子邮件 screen@ibscreen.chg.ru
保 存 Chembase数据库ID: 72791

产品价格信息

请登录

产品别名

标题
Piroxicam
IUPAC标准名
4-hydroxy-2-methyl-1,1-dioxo-N-(pyridin-2-yl)-2H-1λ6,2-benzothiazine-3-carboxamide
IUPAC传统名
4-hydroxy-2-methyl-1,1-dioxo-N-(pyridin-2-yl)-2H-1λ6,2-benzothiazine-3-carboxamide
别名
Improntal
Reudene;
Piroflam
Brexin
Cycladol
Fasax
Flamatrol
Larapam
Pirox
Pirozip

产品登记号

CAS号 36322-90-4

产品性质

应用领域 Antiinflammatory agent
生物活性机理 Reversible inhibitor of cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis.
生物活性机理 The prostaglandins are produced by an enzyme called Cox-1.
生物活性机理 Piroxicam blocks the Cox-1 enzyme, resulting into the disruption of production of prostaglandins.
生物活性机理 Piroxicam also inhibits the migration of leukocytes into sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by the platelets

产品详细信息

参考文献

  • Bernhard, E. et al., Arzneim.-Forsch., 1984, 34, 647, (pKa)
  • Brogden, R.N. et al., Drugs, 1984, 28, 292, (rev, pharmacol)
  • U.S. Pat., 1984, 4 434 164; CA, 100, 191894, (salts)
  • Mihalic, M. et al., Anal. Profiles Drug Subst., 1986, 15, 509, (rev, synth, anal)
  • Svoboda, J. et al., Coll. Czech. Chem. Comm., 1986, 51, 1133, (synth)
  • Tsai, R. et al., Helv. Chim. Acta, 1993, 76, 842, (props)
  • Lee, C.R. et al., Drugs, 1994, 48, 907, (rev)
  • Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 4443, (synonyms)
  • Takcs-Novk, K. et al., Helv. Chim. Acta, 1995, 78, 553, (props, bibl)
  • Maya, M.T. et al., J. Pharm. Biomed. Anal., 1995, 13, 319; 785, (hplc)
  • Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 80
  • Lombardino, J.G. et al., J. Med. Chem., 1973, 16, 493, (synth, pharmacol)
  • Whipple, E.B., Org. Magn. Reson., 1977, 10, 23, (cmr)
  • Wiseman, E.H. et al., Pharmacol. Biochem. Prop. Drug Subst., 1981, 3, 524, (rev, pharmacol)
  • Kojic-Prodic, B. et al., Acta Cryst. B, 1982, 38, 2948, (cryst struct)
  • Bordner, J. et al., Acta Cryst. C, 1984, 40, 989, (cryst struct)