Atenolol

• 产品号: Bio-0737
• CAS号: 29122-68-7
• 分子式: C14H22N2O3
• 分子量: 266.33608

产品别名

• 标题: Atenolol
• IUPAC标准名: 2-{4-[(2S)-2-hydroxy-3-[(propan-2-yl)amino]propoxy]phenyl}acetamide
• IUPAC传统名: 2-{4-[(2S)-2-hydroxy-3-[(propan-2-yl)amino]propoxy]phenyl}acetamide
• 别名: Tenoblock; Atenol; Prenormin; Tenoretic; Atenix; Cuxanorm; Myocord; Selobloc; Tenormin; Totamol; Vasaten

产品登记号

• CAS号: 29122-68-7

产品性质

• 应用领域: Antihypertensive agent
• 应用领域: Can be used to treat cardiovascular diseases and conditions such as hypertension, coronary heart disease, arrhythmias, angina (chest pain) and
• 应用领域: to treat and reduce the risk of heart complications following myocardial infarction (heart attack)
• 生物活性机理: Beta-Adrenergic blocker
• 生物活性机理: Beta1-receptor specific antagonist

参考文献

• U.K. Pat., 1975, 1 391 444; CA, 83, 96783v, (synth)
• Brown, H.C. et al., Clin. Pharmacol. Ther. (St. Louis), 1976, 20, 524, (pharmacol)
• Heel, R.C. et al., Drugs, 1979, 17, 425, (rev)
• Fitzgerald, J.D., Pharmacol. Biochem. Prop. Drug Subst., 1979, 2, 98, (rev, pharmacol)
• Marmo, E., Drugs Exp. Clin. Res., 1980, 6, 639, (rev)
• Caplar, V. et al., Acta Pharm. Jugosl., 1983, 33, 71; CA, 99, 187098, (rev, props)
• Robertson, J.I.S. et al., Drugs, Vol. 25, Suppl. 2: -Blockade in the 1980s - Focus on Atenolol, ADIS Press, 1983, (book)
• Caplar, V. et al., Anal. Profiles Drug Subst., 1984, 13, 1, (rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 3332, (synonyms)
• Mehvar, R. et al., J. Pharm. Sci., 1990, 79, 881; 1991, 80, 207, (pharmacokinet, isomers)
• Wadworth, A.N. et al., Drugs, 1991, 42, 468, (rev)
• Bevinakatti, H.S. et al., J.O.C., 1992, 57, 6003, (bibl, synth, isomers, pmr, ir)
• Carlsen, P.H.J. et al., Acta Chem. Scand., 1994, 48, 273, (synth, ms)
• Cruickshank, J.M. et al., Beta-blockers in Clinical Practice, 2nd edn., Churchill Livingstone, Edinburgh, 1994, (book)
• Kleidernigg, O.P. et al., Chirality, 1994, 6, 411, (synth, hplc, gc-ms)
• McCoy, R.A. et al., J. Clin. Pharmacol., 1994, 34, 816, (pharmacol, isomers)
• Reid, J.L. et al., Ann. N.Y. Acad. Sci., 1995, 763, 673, (rev)
• Kitaori, K. et al., Chem. Pharm. Bull., 1997, 45, 412; 1998, 46, 505-507, (synth, pmr, cmr)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 825
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, TAL475