Vesamicol

• 产品号: Bio-0730
• CAS号: 22232-64-0
• 分子式: C17H25NO
• 分子量: 259.3865

产品别名

• 标题: Vesamicol
• IUPAC标准名: (1R,2R)-2-(4-phenylpiperidin-1-yl)cyclohexan-1-ol
• IUPAC传统名: (1R,2R)-2-(4-phenylpiperidin-1-yl)cyclohexan-1-ol

产品登记号

• CAS号: 22232-64-0

产品性质

• 应用领域: Skeletal muscle relaxant
• 生物活性机理: Potent non-competitive inhibitor of acetylcholine storage.
• 生物活性机理: Can be broadly categorized as a cholinergic physiological antagonist, because it reduces the apparent activity of cholinergic neurons, but does not act at the post-synaptic ACh receptor.
• 生物活性机理: Causes a non-competitive and reversible block of the intracellular transporter responsible for carrying newly synthesised ACh into storage vesicles in the pre-synaptic nerve terminal.
• 生物活性机理: This transport process is driven by a proton gradient between cell organelles and the cytoplasm.
• 生物活性机理: Sympatholytic-alpha.

参考文献

• Kirkland, K.M. et al., J. Chromatogr., 1991, 545, 43, (hplc)
• Prior, C. et al., Gen. Pharmacol., 1992, 23, 1017, (rev)
• Enfange, S.M.N. et al., J. Med. Chem., 1994, 37, 2574, (sar)
• Parsons, S.M. et al., Ann. N.Y. Acad. Sci., 1987, 493, 220, (rev)
• Rogers, G.A. et al., Cell. Mol. Basis Cholinergic Funct., 1987, 333, (rev)
• Marien, M.R. et al., Proc. Natl. Acad. Sci. U.S.A., 1987, 84, 876
• Marshall, I.G. et al., Trends Neurosci., 1987, 10, 174, (rev)
• Estrella, D. et al., Br. J. Pharmacol., 1988, 93, 759, (pharmacol)
• Rogers, G.A. et al., J. Med. Chem., 1989, 32, 1217, (synth, props, cryst struct, sar)