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LY-290181

产品号 Bio-0725 公司名称 InterBioScreen
CAS号 149550-36-7 公司网站 http://www.ibscreen.com
分子式 C20H13N3O3 电 话 +7 49652 40091
分子量 343.33552 传 真 +7 49652 40092
纯 度 电子邮件 screen@ibscreen.chg.ru
保 存 Chembase数据库ID: 179864

产品价格信息

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产品别名

标题
LY-290181
IUPAC标准名
2-amino-4-(3-nitrophenyl)-4H-benzo[h]chromene-3-carbonitrile
IUPAC传统名
2-amino-4-(3-nitrophenyl)-4H-benzo[h]chromene-3-carbonitrile

产品登记号

CAS号 149550-36-7

产品性质

应用领域 Antiproliferative
应用领域 Antimitotic
应用领域 Antiarteriosclerotic
生物活性机理 Metalloproteinase inhibitor
生物活性机理 Protein kinase C inhibitor
生物活性机理 Myocyte proliferation inhibitor

产品详细信息

参考文献

  • 1. S. Chandrasekhar, A. K. Harvey, C. P. Dell, S. J. Ambler, C. W. Smith Identification of a Novel Chemical Series that Blocks Interleukin-1-Stimulated Metalloprotease Activity in Chondrocytes
  • Journal of Pharmacology and Experimental Therapeutics 273(3): 1519-1528, 1995
  • 2. D. L. Wood, D. Panda, T. R. Wiernicki, L. Wilson, M. A. Jordan, J. P.
  • Singh nhibition of Mitosis and Microtubule Function through Direct Tubulin Binding by a Novel Antiproliferative Naphthopyran LY290181 Mol. Pharmacol. September 1, 1997 52:437-444
  • 3. Birch K. A., Heath W. F., Hermling R. N., Johnston C. M., Stramm L., Dell C., Smith C., Williamson J. R., Miller A. R. (1996)
  • LY290181, an inhibitor of diabetes-induced vascular dysfunction, blocks protein kinase C-stimulated transcription factor binding to phorbol response element. Diabetes 45:642?50.