Triamcinolone acetonide

• 产品号: Bio-0665
• CAS号: 76-25-5
• 分子式: C24H31FO6
• 分子量: 434.4977432

产品别名

• 标题: Triamcinolone acetonide
• IUPAC标准名: (1S,2S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^2,^9.0^4,^8.0^1^3,^1^8]icosa-14,17-dien-16-one
• IUPAC传统名: (1S,2S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^2,^9.0^4,^8.0^1^3,^1^8]icosa-14,17-dien-16-one
• 别名: Aristocort; Fluoxiprednisolone; Kenacort; Lederspan; Volon

产品登记号

• CAS号: 76-25-5

产品性质

• 应用领域: Antiproliferative
• 应用领域: Antipruritic
• 应用领域: Antiinflammatory agent
• 生物活性机理: Glucocorticoid
• 生物活性机理: Enhances the effect of sympatholytics-beta on cyclic-AMP production
• 生物活性机理: May produce direct smooth muscle relaxation
• 生物活性机理: Topical admin
• 生物活性机理: Vasoconstrictor
• 生物活性机理: Possible mechanisms: may decrease the number of inflammatory-cells
• 生物活性机理: May inhibit bronchoconstrictor mechanisms
• 生物活性机理: Exact bronchodilator mechanism unknown

参考文献

• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 586B, (nmr)
• Bernstein, S. et al., J.A.C.S., 1956, 78, 5693, (synth)
• Fried, J. et al., J.A.C.S., 1958, 80, 2338, (synth, pharmacol)
• Bernstein, S. et al., J.A.C.S., 1959, 81, 1689, (synth, acetonide)
• Florey, K., Anal. Profiles Drug Subst., 1972, 1, 367; 397; 423, (rev)
• Toft, P. et al., Can. J. Pharm. Sci., 1972, 7, 53, (ms)
• Fiegel, G., Arzneim.-Forsch., 1975, 25, 560, (rev)
• Zbinovsky, V. et al., Anal. Profiles Drug Subst., 1977, 6, 579, (rev)
• Sieh, D.H., Anal. Profiles Drug Subst., 1982, 11, 593; 615; 651, (rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6222; 7100; 7152
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 739
• van Leusen, D. et al., J.O.C., 1994, 59, 7534, (synth, acetonide)
• Jeal, W. et al., Drugs, 1997, 53, 257-280, (rev, acetonide)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, AQX250; AQY375; AQX500; AQX750