您当前所在的位置:首页 > 产品中心 > 产品信息
Lamivudine_分子结构_CAS_134678-17-4)
点击图片或这里关闭

Lamivudine

产品号 Bio-0652 公司名称 InterBioScreen
CAS号 134678-17-4 公司网站 http://www.ibscreen.com
分子式 C8H11N3O3S 电 话 +7 49652 40091
分子量 229.25624 传 真 +7 49652 40092
纯 度 电子邮件 screen@ibscreen.chg.ru
保 存 Chembase数据库ID: 590

产品价格信息

请登录

产品别名

标题
Lamivudine
IUPAC标准名
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one
IUPAC传统名
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one
别名
Zeffix
Epivir

产品登记号

CAS号 134678-17-4

产品性质

应用领域 Potent antiviral agent
应用领域 Active against hepatitis B virus and human immunodeficiency virus
生物活性机理 HIV reverse transcriptase inhibitor

产品详细信息

参考文献

  • Soudeyns, H. et al., Antimicrob. Agents Chemother., 1991, 35, 1386, (pharmacol)
  • Beach, J.W. et al., J.O.C., 1991, 56, 6503; 1992, 57, 2217, (synth, bibl, pharmacol)
  • Coates, J.A.V. et al., Antimicrob. Agents Chemother., 1992, 36, 202, (pharmacol)
  • Schinazi, R.F. et al., Antimicrob. Agents Chemother., 1992, 36, 672, (pharmacol)
  • Eur. Pat., 1992, Glaxo, 517 145; CA, 118, 191756p, (synth, cryst struct)
  • Chang, C.N. et al., J. Biol. Chem., 1992, 267, 22414, (pharmacol)
  • Humber, D.C. et al., Tet. Lett., 1992, 33, 4625, (synth, bibl)
  • Skalski, V. et al., J. Biol. Chem., 1993, 268, 23234, (pharmacol)
  • Jeong, L.S. et al., J. Med. Chem., 1993, 36, 181; 2627, (synth, bibl, pharmacol, pmr, uv)
  • Storer, R. et al., Nucleosides Nucleotides, 1993, 12, 225, (synth, abs config)
  • van Leeuwen, R. et al., J. Infect. Dis., 1995, 171, 1166; 1438, (clin trials)
  • Perry, C.M. et al., Drugs, 1997, 54, 657-680, (rev)
  • Harris, R.K. et al., J.C.S. Perkin 1, 1997, 2653-2659, (cryst struct, ir, cmr, pmr)
  • Jarvis, B. et al., Drugs, 1999, 58, 101-141
  • Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 622