Colchicine

• 产品号: Bio-0634
• CAS号: 64-86-8
• 分子式: C22H25NO6
• 分子量: 399.437

产品别名

• 标题: Colchicine
• IUPAC标准名: N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide
• IUPAC传统名: N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide
• 别名: Colchiceine methyl ether; Colchisol; Artrichine; Colsaloid

产品登记号

• CAS号: 64-86-8

产品性质

• 应用领域: Immunosuppressive
• 应用领域: Cytostatic
• 应用领域: Antirheumatic
• 应用领域: Potential HIV inhibitor
• 生物来源: Chief alkaloid from Colchicum autumnale, many other Colchicum spp., several Merendera spp., Gloriosa superba and others (Liliaceae)
• 生物活性机理: Leukocyte migration inhibitor
• 生物活性机理: Phagocytosis inhibitor
• 生物活性机理: Interferes with kinin formation
• 生物活性机理: Reduces phagocytosis with inflammatory
• 生物活性机理: Response abatement
• 生物活性机理: Exact mechanism unknown

参考文献

• J.Am.Coll.Cardiol. (26, No. 6, 1549-57, 1995)
• Local delivery of biodegradable microparticles containing colchicine or a colchicine analogue: effects on restenosis and implications for catheter-based drug delivery.