Captopril

• 产品号: Bio-0622
• CAS号: 62571-86-2
• 分子式: C9H15NO3S
• 分子量: 217.2853

产品别名

• 标题: Captopril
• IUPAC标准名: (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
• IUPAC传统名: (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
• 别名: Capoten; Capace; Acenorm; Acepril

产品登记号

• CAS号: 62571-86-2

产品性质

• 应用领域: Exp. drug for treatment of myocardial infarction
• 应用领域: Smooth muscle relaxant
• 简要说明: Diastereomers
• 应用领域: Antihypertensive agent
• 应用领域: Drug used for diagnosis and treatment of renin-dependent hypertension
• 生物活性机理: ACE inhibitor
• 生物活性机理: May inhibit local angiotensin 2 at vascular and renal sites so attenuating catecholamine release
• 生物活性机理: May increase prostaglandin synthesis
• 生物活性机理: Increases urinary excretion of PGE2
• 生物活性机理: increases plasma-renin activity resulting from loss of negative feedback on renin release due to reduced angiotensin-2 concentration
• 生物活性机理: increases plasma levels of PGE2 and PGE2-alpha metabolites.
• 生物活性机理: increased sodium-excretion
• 生物活性机理: increased plasma-renin causes decrease in aldosterone-secretion resulting in: small increases in serum-potassium
• 生物活性机理: decreases plasma-angiotensin-2 concentration
• 生物活性机理: decrease in plasma-volume
• 生物活性机理: apparent primary action involves suppression of the renin-angiotensin-aldosterone-system
• 生物活性机理: angiotensin-antagonist

参考文献

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