D-Penicillamine

• 产品号: Bio-0578
• CAS号: 52-67-5
• 分子式: C5H11NO2S
• 分子量: 149.21134

产品别名

• 标题: D-Penicillamine
• IUPAC标准名: (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid
• IUPAC传统名: (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid

产品登记号

• CAS号: 52-67-5

产品性质

• 应用领域: Antiinflammatory
• 应用领域: Antirheumatic
• 应用领域: Chelating agent used in therapy of metal poisoning, and for Wilson's disease, scleroderma and rheumatoid arthritis
• 生物活性机理: Chelating agent recommended for the removal of excess copper in patients with Wilson's disease.
• 生物活性机理: From in vitro studies which indicate that one atom of copper combines with two molecules of penicillamine.
• 生物活性机理: Penicillamine also reduces excess cystine excretion in cystinuria.
• 生物活性机理: This is done, at least in part, by disulfide interchange between penicillamine and cystine, resulting in formation of penicillamine-cysteine disulfide,
• 生物活性机理: a substance that is much more soluble than cystine and is excreted readily.
• 生物活性机理: Penicillamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed.
• 生物活性机理: The mechanism of action of penicillamine in rheumatoid arthritis is unknown although it appears to suppress disease activity.
• 生物活性机理: Unlike cytotoxic immunosuppressants, penicillamine markedly lowers IgM rheumatoid factor but produces no significant depression in absolute levels of serum immunoglobulins.
• 生物活性机理: Also unlike cytotoxic immunosuppressants which act on both, penicillamine in vitro depresses T-cell activity but not B-cell activity.

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