Rifaximin

• 产品号: Bio-0556
• CAS号: 80621-81-4
• 分子式: C43H51N3O11
• 分子量: 785.87854

产品别名

• 标题: Rifaximin
• IUPAC标准名: (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.1^4,^7.0^5,^3^5.0^2^6,^3^4.0^2^7,^3^2]heptatriaconta-1,3,5(35),9,19,21,25(36),26(34),28,30,32-undecaen-13-yl acetate
• IUPAC传统名: (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.1^4,^7.0^5,^3^5.0^2^6,^3^4.0^2^7,^3^2]heptatriaconta-1,3,5(35),9,19,21,25(36),26(34),28,30,32-undecaen-13-yl acetate
• 别名: Rifacol; Normix; Rifaxidin

产品登记号

• CAS号: 80621-81-4

产品性质

• 应用领域: Antibacterial agent
• 应用领域: Antibiotic
• 生物活性机理: Inhibits bacterial RNA synthesis by binding to bacterial DNA-dependent RNA polymerase

参考文献

• de Angelis, L., Drugs of the Future, 1982, 7, 260, (rev)
• Brufani, M. et al., J. Antibiot., 1984, 37, 1611, (synth, pmr, pharmacol)
• Marchi, E. et al., J. Med. Chem., 1985, 28, 960, (synth, pharmacol)
• Venturini, A.P. et al., Chemioterapia, 1986, 5, 257; 263, (pharmacol, tox)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 200
• Gillis, J.C. et al., Drugs, 1995, 49, 467, (rev)