Enoxolone

• 产品号: Bio-0549
• CAS号: 471-53-4
• 分子式: C30H46O4
• 分子量: 470.68384

产品别名

• 标题: Enoxolone
• IUPAC标准名: (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
• IUPAC传统名: (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
• 别名: Glycyrrhetinic acid; Glycyrrhetin; Biosone; Biogastrone acid; Uralenic acid; Glycyrrhetic acid; Rhetinic acid

产品登记号

• CAS号: 471-53-4

产品性质

• 应用领域: Antibacterial, antitussive agent
• 应用领域: Antiinflammatory
• 应用领域: Used in treatment of noninfective inflammatory disorders (skin, mouth, etc.)
• 生物来源: Aglycone from Glycyrrhiza glabra and some other plants
• 生物活性机理: Calcium-mobilizer in P815 cells in-vitro
• 生物活性机理: Reported to trap hydroxyl radicals to suppress rat liver injury caused by ischemia-perfusion
• 生物活性机理: Reported to inhibit reactive oxygen species generation by human neutrophils in-vitro

参考文献

• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 1057D, (ir)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 596A, (nmr)
• Beaton, J.M. et al., J.C.S., 1955, 3126, (synth)
• Mer, J., Am. Perfum. Aromat., 1959, 74, 39, (isol)
• U.K. Pat., 1960, 843 133; CA, 55, 2027i, (Carbenoxolone)
• Witz, P. et al., Bull. Soc. Chim. Fr., 1963, 1101, (cd)
• Budzikiewicz, H. et al., J.A.C.S., 1963, 85, 3688, (ms)
• Murav'ev, I.A. et al., CA, 1966, 69, 44029v, (rev)
• Canonica, L. et al., Gazz. Chim. Ital., 1967, 97, 1347; 1968, 98, 602, (Glycyrrhetol)
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• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, GIE000; BGD000; GIEO5O; CBO500