Zonisamide

• 产品号: Bio-0532
• CAS号: 68291-97-4
• 分子式: C8H8N2O3S
• 分子量: 212.22572

产品别名

• 标题: Zonisamide
• IUPAC标准名: 1,2-benzoxazol-3-ylmethanesulfonamide
• IUPAC传统名: 1,2-benzoxazol-3-ylmethanesulfonamide
• 别名: Excegran; Exogran; Exegran; Aleviatin; Fenisoxine

产品登记号

• CAS号: 68291-97-4

产品性质

• 应用领域: Anticonvulsant
• 应用领域: Antiepileptic agent
• 生物活性机理: Binds to sodium channels, voltage sensitive calcium channels and to a lesser extent carbonic anhydrase, this blocks or suppresses neuronal depolarization and hypersynchronization

参考文献

• Uno, H. et al., J. Med. Chem., 1979, 22, 180, (synth, pharmacol)
• Masuda, Y. et al., Arzneim.-Forsch., 1980, 30, 477, (pharmacol)
• Ito, T. et al., Arzneim.-Forsch., 1982, 32, 1581
• Uno, H. et al., Chem. Pharm. Bull., 1982, 30, 333, (synth)
• Matsumoto, K. et al., Arzneim.-Forsch., 1983, 33, 961, (metab)
• Matsuno, Y. et al., Arzneim.-Forsch., 1987, 37, 1124; 1131, (pharmacol)
• Lisgarten, J.N. et al., Acta Cryst. C, 1988, 44, 2013, (cryst struct)
• Walker, R.M. et al., Fundam. Appl. Toxicol., 1988, 11, 333, (tox, dog)
• Berry, D.J., J. Chromatogr., 1990, 534, 173, (hplc)
• Henry, T.R. et al., The Medical Treatment of Epilepsy, (Eds. Resor, S.R. et al), M. Dekker, 1992, 423, (rev)
• Stiff, D.D. et al., Xenobiotica, 1992, 22, 1, (metab)
• Peters, D.H. et al., Drugs, 1993, 45, 760, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 314
• Furuno, K. et al., J. Chromatogr., B: Biomed. Appl., 1994, 656, 456, (hplc)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, BCE750