Albendazole sulfone

• 产品号: Bio-0400
• CAS号: 75184-71-3
• 分子式: C12H15N3O4S
• 分子量: 297.3302

产品别名

• 标题: Albendazole sulfone
• IUPAC标准名: methyl N-[5-(propane-1-sulfonyl)-1H-1,3-benzodiazol-2-yl]carbamate
• IUPAC传统名: methyl N-[5-(propane-1-sulfonyl)-1H-1,3-benzodiazol-2-yl]carbamate
• 别名: Alben; Valbazen; Helmintal; Zentel; Bermosol; Eskazole

产品登记号

• CAS号: 75184-71-3

产品性质

• 应用领域: Anthelmintic
• 应用领域: Investigated for treatment of chronic stronglyoidiasis, and for microsporidiosis in AIDS patients
• 生物活性机理: Causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin,
• 生物活性机理: thus inhibiting its polymerization or assembly into microtubules.
• 生物活性机理: The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores.
• 生物活性机理: Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP),
• 生物活性机理: which is the energy required for the survival of the helminth.
• 生物活性机理: Due to diminished energy production, the parasite is immobilized and eventually dies.
• 生物活性机理: Also has been shown to inhibit the enzyme fumarate reductase, which is helminth-specific.
• 生物活性机理: This action may be considered secondary to the effect

参考文献

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