Acefylline

• 产品号: Bio-0276
• CAS号: 652-37-9
• 分子式: C9H10N4O4
• 分子量: 238.2001

产品别名

• 标题: Acefylline
• IUPAC标准名: 2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)acetic acid
• IUPAC传统名: 2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)acetic acid
• 别名: Theophylline-7-acetic acid; 1,3-Dimethylxanthin-7-ylacetic acid; Aminodal; Stenofillina

产品登记号

• CAS号: 652-37-9

产品性质

• 应用领域: Spasmolytic, cardiotonic, diuretic and smooth muscle relaxant
• 应用领域: Bronchodilator
• 生物活性机理: Lipoprotein lipase inhibitor
• 生物活性机理: Triglyceride lipase activator
• 生物活性机理: Glucose transport blocker
• 生物活性机理: Fatty acid metabolism inhibitor

参考文献

• U.K. Pat., 1965, 998 971; CA, 63, 9756g, (pharmacol)
• Maslankiewicz, A. et al., Pol. J. Chem. (Rocz. Chem.), 1975, 49, 1935, (synth)
• Zuidema, J. et al., Pharm. Weekbl., 1978, 113, 605, (pharmacol)
• IARC Monog., 1980, 24, 39; Suppl. 7, 171, (rev, tox)
• Szatmari, I. et al., Eur. J. Drug Metab. Pharmacokinet., 1984, 9, 11; 17, (metab, depogen)
• Priimenko, B.A. et al., Farm. Zh. (Kiev), 1985, 40, (synth)
• Ger. Pat., 1987, 3 633 492; CA, 107, 7013t, (synth, depogen)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 1178
• Kapui, Z. et al., Thromb. Res., 1992, 66, 693, (pharmacol, depogen)
• Bcskei, Z. et al., Acta Cryst. C, 1995, 51, 1587, (cryst struct, depogen)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 1651