Scopoletin

• 产品号: Bio-0208
• CAS号: 92-61-5
• 分子式: C10H8O4
• 分子量: 192.16812

产品别名

• 标题: Scopoletin
• IUPAC标准名: 7-hydroxy-6-methoxy-2H-chromen-2-one
• IUPAC传统名: 7-hydroxy-6-methoxy-2H-chromen-2-one
• 别名: Aesculetin 6-methyl ether; Chrysatropic acid; Escopoletin; Gelseminic acid; beta-Methylaesculetin; Buxuletin; Scopoletol; Baogongteng B

产品登记号

• CAS号: 92-61-5

产品性质

• 应用领域: Antitumour agent
• 应用领域: Antispasmodic
• 生物来源: Occurs widely in the plant world, for example, the root of Gelsemium sempervirens, Atropa belladonna, Convolvulus scammonia, Ipomoea orizabensis, Prunus serotina, Fabiana imbricata and also Diospyros spp., Peucedanum spp., Heracleum spp., Skimmia spp. Also occurs in the Chinese crude drug Toki (from Angelica acutiloba )
• 生物活性机理: C (PKC) protein kinase inhibitor

参考文献

• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 324B, (ir)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1314B, (nmr)
• Seka, R. et al., Ber., 1931, 64, 909
• Head, F.G.H. et al., J.C.S., 1931, 1241, (synth)
• Karrer, W. et al., Konstitution und Vorkommen der Organischen Pflanzenstoffe, 2nd edn., Birkhuser Verlag, Basel, 1972, nos. 1328; 1329, (occur)
• Gonzlez, A.G. et al., An. Quim., 1973, 69, 1013, (pmr)
• Tanaka, S. et al., Arzneim.-Forsch., 1977, 27, 2039, (isol)
• Herath, W.H.M. et al., Phytochemistry, 1978, 17, 1007, (isol)
• Ishibura, N. et al., Z. Naturforsch., C, 1979, 34, 628
• Murray, R.D.H. et al., The Natural Coumarins, J. Wiley, 1982, (occur, rev)
• Abu-Eittah, R.H. et al., Can. J. Chem., 1985, 63, 1173, (uv)
• Koul, S.K. et al., Indian J. Chem., Sect. B, 1987, 26, 574, (synth)
• Udovin, A.D. et al., Khim. Prir. Soedin., 1987, 23, 796; Chem. Nat. Compd. (Engl. Transl.), 1987, 23, 660, (cmr)
• Wollenweber, E. et al., Fitoterapia, 1989, 60, 460, (isol, derivs)
• Mizuno, M. et al., Phytochemistry, 1992, 31, 717, (deriv)
• Hauer, H. et al., Arch. Pharm. (Weinheim, Ger.), 1995, 328, 737, (synth)