Nisoldipine

• 产品号: Bio-0177
• CAS号: 63675-72-9
• 分子式: C20H24N2O6
• 分子量: 388.41436

产品别名

• 标题: Nisoldipine
• IUPAC标准名: 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• IUPAC传统名: 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 别名: Sular; Nisocor

产品登记号

• CAS号: 63675-72-9

产品性质

• 应用领域: Coronary vasodilator
• 应用领域: Antihypertensive agent
• 生物活性机理: Calcium channel antagonist
• 生物活性机理: By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum
• 生物活性机理: inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes.
• 生物活性机理: The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells,
• 生物活性机理: causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue,
• 生物活性机理: decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload

参考文献

• Ger. Pat., 1977, 2 549 568; CA, 87, 84831d, (synth, pharmacol)
• Kazda, S. et al., Arzneim.-Forsch., 1980, 30, 2144, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 28th/29th edn., Pharmaceutical Press, 1982, 13022
• Kazda, S. et al., New Drugs Annu.: Cardiovasc. Drugs, 1983, 1, 243, (rev)
• Hugenholtz, P.G. et al., Nisoldipine 1987, Springer-Verlag, Berlin, 1987, (book)
• Ahr, H.J. et al., Arzneim.-Forsch., 1988, 38, 1093; 1099; 1105, (pharmacokinet)
• Friedel, H.A. et al., Drugs, 1988, 36, 682, (rev)
• Fossheim, R. et al., J. Med. Chem., 1988, 31, 300, (cryst struct)
• Mitchell, J. et al., J. Clin. Pharmacol., 1993, 33, 46, (rev)
• Langtry, H.D. et al., Drugs, 1997, 54, 867-884, (rev)