Methotrexate

• 产品号: Bio-0134
• CAS号: 59-05-2
• 分子式: C20H22N8O5
• 分子量: 454.43928

产品别名

• 标题: Methotrexate
• IUPAC标准名: (2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
• IUPAC传统名: (2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
• 别名: Mexate; Maxtrex; Extexate; Amethopterin; Methylaminopterin

产品登记号

• CAS号: 59-05-2

产品性质

• 应用领域: Antineoplastic and antipsoriatic agent
• 应用领域: Used in the treatment of rheumatoid arthritis.
• 生物活性机理: Dihydrofolate reductase inhibitor

参考文献

• Seeger, D.R. et al., J.A.C.S., 1949, 71, 1753, (synth, uv)
• Pastore, E.J., Ann. N.Y. Acad. Sci., 1971, 186, 43, (pmr)
• Piper, J.R. et al., J. Het. Chem., 1974, 11, 279, (synth)
• Chamberlain, A.R. et al., Anal. Profiles Drug Subst., 1976, 5, 283, (anal)
• Suster, D.C. et al., Rev. Roum. Chim., 1977, 22, 1195-1207, (synth, uv)
• IARC Monog., 1981, 26, 267; Suppl. 7, 241; Suppl. 6, 372, (rev, tox)
• Piper, J.R. et al., J. Med. Chem., 1982, 25, 182-187; 1983, 26, 291-294, (homologues)
• Hambley, T.W. et al., J.A.C.S., 1986, 108, 2103, (cryst struct)
• Kimura, K. et al., Prog. Cancer Res. Ther., 1986, 33, (book)
• Cheung, H.T. et al., Heterocycles, 1987, 25, 507, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 5672
• Matherly, L.H. et al., Pharmacol. Ther., 1987, 35, 27, (rev, metab, pharmacol)
• Faupel, P. et al., Angew. Chem., Int. Ed., 1988, 27, 423, (uv, cd, conformn)
• Rahman, L.K. et al., Med. Res. Rev., 1988, 8, 95, (rev, chem)
• DeGraw, J.I. et al., J. Labelled Compd. Radiopharm., 1989, 27, 112, (synth, labelled compd)
• Wilke, W.S., Methotrexate Therapy in Rheumatic Disease, Marcel Dekker (Ed. Wilke, W.S.), 1989, (book)
• Rosowsky, A. et al., Prog. Med. Chem., 1989, 26, 1, (sar, rev)
• Mathers, D. et al., Inflammatory Dis. Ther., 1992, 9, 287, (rev)
• Bannwarth, B. et al., Drugs, 1994, 47, 25, (use, rev)
• Albertioni, F. et al., Clin. Chem. (Winston-Salem, N.C.), 1996, 42, 39, (hplc, anal)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 584
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 9th edn., Van Nostrand Reinhold, 1996, MDV500; MDV600