Clobetasol (O-propionate)

• 产品号: Bio-0120
• CAS号: 25122-46-7
• 分子式: C25H32ClFO5
• 分子量: 466.9699832

产品别名

• 标题: Clobetasol (O-propionate)
• IUPAC标准名: (1R,2S,13S,14R,15S,17S)-14-(2-chloroacetyl)-1-fluoro-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-dien-14-yl propanoate
• IUPAC传统名: (1R,2S,13S,14R,15S,17S)-14-(2-chloroacetyl)-1-fluoro-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-dien-14-yl propanoate
• 别名: Decloban; Temovate; Dermovate; Butavate; Clobesol; Myalone

产品登记号

• CAS号: 25122-46-7

产品性质

• 应用领域: Antiinflammatory
• 应用领域: Antiallergic agent
• 应用领域: Dermatological agent
• 应用领域: Used to treat eczema and psoriasis
• 生物活性机理: Corticosteroid

参考文献

• Ger. Pat., 1969, Glaxo, 1 902 340; CA, 72, 44021y, (synth, pharmacol)
• Tamura, J. et al., J. Toxicol. Sci., 1980, 5, 45; 177, (tox)
• Allenby, C.F. et al., Br. J. Dermatol., 1981, 104, 179
• Topical Corticosteroids, (Eds. Maibach, H.I. et al), Karger, 1992, (book)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 726
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 10195; 10400, (synonyms)
• Khalid, M. et al., Int. J. Dermatol., 1995, 34, 203, (clin trial)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CMW300; CMW400