Carmustine

• 产品号: Bio-0118
• CAS号: 154-93-8
• 分子式: C5H9Cl2N3O2
• 分子量: 214.04986

产品别名

• 标题: Carmustine
• IUPAC标准名: 1,3-bis(2-chloroethyl)-1-nitrosourea
• IUPAC传统名: 1,3-bis(2-chloroethyl)-1-nitrosourea
• 别名: Nitrumon; Carmubris; Becenum

产品登记号

• CAS号: 154-93-8

产品性质

• 应用领域: Antineoplastic agent
• 应用领域: Used to treat gliomas, glioblastoma multiforme, medulloblastoma and astrocytoma, multiple myeloma and lymphoma (Hodgkin's and non-Hodgkin).
• 生物活性机理: Alkylating agent in cancer chemotherapy

参考文献

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• Lien, E.J. et al., Spectrosc. Lett., 1972, 5, 293, (pmr)
• Thompson, G.R. et al., Toxicol. Appl. Pharmacol., 1972, 21, 405, (tox)
• Gombar, C.T. et al., Diss. Abstr. Int., B, 1980, 40, 5223; 5686, (props)
• IARC Monog., 1981, 26, 79; Suppl. 6, 116; Suppl. 7, 150, (rev, tox)
• Lown, J.W. et al., J.O.C., 1981, 46, 5309, (synth, cmr, N-15 nmr)
• Paoletti, R. et al., Am. J. Cardiol., 1983, 52, 21, (rev)
• Reed, D.J. et al., Anticancer Drugs: Reactive Metabolism and Drug Interactions, (Ed. Powis, G.) Pergamon Press, 1994, 187, (rev)
• Wiencke, J.K. et al., Mutat. Res., 1995, 339, 91, (rev, genotox)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 550
• Kaba, S.E. et al., Drugs, 1997, 53, 235, (use, rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, BIF750