应用领域
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Antiprotozoal
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应用领域
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Antiparasitic agent
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应用领域
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Active (in animals and in vitro) against Pneumocystis carinii, Plasmodia, and tachyzoite and cyst forms of Toxoplasma gondii
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应用领域
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Orally active antiprotozoal used for treatment of AIDS-associated pneumonia
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生物活性机理
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The mechanism of action against Pneumocystis carinii has not been fully elucidated
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生物活性机理
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In Plasmodium species, the site of action appears to be the cytochrome bc1 complex (Complex III).
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生物活性机理
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Several metabolic enzymes are linked to the mitochondrial electron transport chain via ubiquinone.
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生物活性机理
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Inhibition of electron transport by atovaquone will result in indirect inhibition of these enzymes.
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生物活性机理
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The ultimate metabolic effects of such blockade may include inhibition of nucleic acid and ATP synthesis.
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