Vinblastine

• 产品号: Bio-0111
• CAS号: 865-21-4
• 分子式: C46H58N4O9
• 分子量: 810.97412

产品别名

• 标题: Vinblastine
• IUPAC标准名: methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^4,^1^2.0^5,^1^0]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2,4,6,13-tetraene-10-carboxylate
• IUPAC传统名: methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^4,^1^2.0^5,^1^0]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2,4,6,13-tetraene-10-carboxylate
• 别名: Vincaleukoblastine; Vincaleucoblastine

产品登记号

• CAS号: 865-21-4

产品性质

• 应用领域: Antineoplastic agent
• 应用领域: Used widely in the treatment of Hodgkin's disease and other lymphomas
• 生物来源: Alkaloid from Vinca rosea ( Catharanthus roseus ) (Apocynaceae)
• 生物活性机理: Binds tubulin, inhibiting the assembly of microtubules

参考文献

• Aldrich Library of Infrared Spectra, 3rd edn., 1981, 1511H, (ir)
• Neuss, N. et al., J.A.C.S., 1959, 81, 4754; 1962, 84, 1509; 1964, 86, 1440, (uv, ir, pmr, struct)
• Svoboda, G.H. et al., J. Pharm. Sci., 1964, 53, 1227
• Bommer, P. et al., J.A.C.S., 1964, 86, 1439, (ms)
• Moncrief, J.W. et al., J.A.C.S., 1965, 87, 4963, (cryst struct)
• Burns, J.H., Anal. Profiles Drug Subst., 1972, 1, 443, (rev, uv, ir, pmr, anal)
• Wenkert, E. et al., J.A.C.S., 1973, 95, 4990
• Catharanthus Alkaloids, (Eds, Taylor, W.I. et al), M. Dekker, 1975, (pharmacol)
• Wenkert, E. et al., Helv. Chim. Acta, 1975, 58, 1560, (cmr)
• Sieber, S.M. et al., Cancer Treat. Rep., 1976, 60, 1127, (pharmacol)
• Dorman, D.E. et al., Org. Magn. Reson., 1976, 8, 413, (cmr)
• Atta-ur-Rahman et al., Z. Naturforsch., B, 1976, 31, 1416, (rev)
• Kutney, J.P., J. Nat. Prod., 1977, 40, 107, (rev)
• Hassam, S.B. et al., Tet. Lett., 1978, 1681, (biosynth)
• Potier, P. et al., J.A.C.S., 1979, 101, 2243, (synth)
• Brade, W. et al., Contrib. Oncol., (Eds). Vindesine. S. Karger, Basel, Switz., 1981, 6, (book)
• Baxter, R.L. et al., Chem. Comm., 1982, 791, (biosynth)
• Kutney, J.P. et al., Helv. Chim. Acta, 1982, 65, 2088, (biosynth)
• McLauchlan, W.R. et al., Tetrahedron, 1983, 39, 3777, (biosynth)
• Magnus, P. et al., Stud. Org. Chem. (Amsterdam), 1986, 25, 203; 257, (synth, revs)
• Endo, T. et al., Planta Med., 1987, 53, 479
• Kutney, J.P. et al., Heterocycles, 1988, 27, 1845, (synth)
• Kuehne, M.E. et al., Alkaloids (N.Y.), 1990, 37, 77, (synth, rev)
• Neuss, N. et al., Alkaloids (N.Y.), 1990, 37, 229, (pharmacol)
• Magnus, P. et al., J.A.C.S., 1990, 112, 8210; 1992, 114, 10232, (synth)
• Kuehne, M.E. et al., J.O.C., 1991, 56, 513, (synth)
• Muhtadi, F.J. et al., Anal. Profiles Drug Subst., 1992, 21, 611, (rev)
• Bornmann, W.G. et al., J.O.C., 1992, 57, 1752, (synth)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 504
• Parish, C.A. et al., Tetrahedron, 1998, 54, 15739-15759, (cd)
• Yokoshima, S. et al., J.A.C.S., 2002, 124, 2137-2139, (synth)
• Hardouin, C. et al., Org. Lett., 2002, 4, 1151-1153, (synth)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, VGU750; VKZ000; VLA000