Pemetrexed Disodium Heptahydrate

• 产品号: Bio-0078
• CAS号: 357166-29-1
• 分子式: C20H33N5Na2O13
• 分子量: 597.48126

产品别名

• 标题: Pemetrexed Disodium Heptahydrate
• IUPAC标准名: disodium (2S)-2-{[4-(2-{2-amino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioate heptahydrate
• IUPAC传统名: disodium (2S)-2-{[4-(2-{2-amino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioate heptahydrate
• 别名: Alimta

产品登记号

• CAS号: 357166-29-1

产品性质

• 应用领域: Antineoplastic agent
• 成盐信息: 2 Na+, 7 H2O
• 生物活性机理: Thymidylate synthase inhibitor

参考文献

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• Hamilton, C.L. et al., J. Chromatogr., B: Biomed. Appl., 1994, 654, 297-303, (hplc)
• Rinaldi, D.A. et al., J. Clin. Oncol., 1995, 13, 2842-2850, (clin trial)
• Shih, C. et al., Cancer Res., 1997, 57, 1116-1123, (pharmacol)
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• Calvert, A.H. et al., Br. J. Cancer, 1998, 78, 35-40, (rev)
• Graul, A. et al., Drugs of the Future, 1998, 23, 498-507, (rev)
• Taylor, E.C. et al., Tet. Lett., 1999, 40, 4023-4026, (synth)