Olopatadine Hydrochloride

• 产品号: Bio-0072
• CAS号: 140462-76-6
• 分子式: C21H24ClNO3
• 分子量: 373.87316

产品别名

• 标题: Olopatadine Hydrochloride
• IUPAC标准名: 2-[(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl]acetic acid hydrochloride
• IUPAC传统名: 2-[(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl]acetic acid hydrochloride
• 别名: Patanase; Opatanol; Patanol; Pataday; Patanol S

产品登记号

• CAS号: 140462-76-6

产品性质

• 应用领域: Antiallergic agent
• 应用领域: Used in the treatment of allergic rhinitis, urticaria, allergic conjunctivitis and asthma
• 成盐信息: HCl
• 生物活性机理: Histamine H1-receptor antagonist,
• 生物活性机理: Mediator release inhibitor

参考文献

• Eur. Pat., 1987, Kyowa Hakko Kogyo, 235 796; CA, 108, 167330, (synth, pharmacol)
• Oshima, E. et al., J. Med. Chem., 1992, 35, 2074, (synth, cryst struct, pharmacol)
• Ikeda, K. et al., Int. Arch. Allergy Appl. Immunol., 1995, 106, 157, (pharmacol)
• Ikemura, T. et al., Int. Arch. Allergy Appl. Immunol., 1996, 110, 57; 64, (pharmacol)
• Sharif, N.A. et al., J. Pharmacol. Exp. Ther., 1996, 278, 1252, (pharmacol)
• Berdy, G.J. et al., Clin. Ther., 2000, 22, 826-833; 2001, 23, 1272-1280, (pharmacol)