Irinotecan

• 产品号: Bio-0054
• CAS号: 97682-44-5
• 分子式: C33H38N4O6
• 分子量: 586.67802

产品别名

• 标题: Irinotecan
• IUPAC标准名: (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate
• IUPAC传统名: (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate
• 别名: Camptosar; Topotecin; Camptetin; Campto

产品登记号

• CAS号: 97682-44-5

产品性质

• 应用领域: Antineoplastic agent
• 应用领域: Use is in colon cancer
• 生物活性机理: Topoisomerase I inhibitor

参考文献

• Boisseau, M. et al., Expert Opin. Invest. Drugs, 1996, 5, 613, (rev)
• Henegar, K.E. et al., J.O.C., 1997, 62, 6588-6597, (synth)
• Robert, J. et al., Drugs of Today (Barcelona), 1998, 34, 777-803, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 543
• Nitta, K. et al., Recent Adv. Chemother., Proc. Int. Congr. Chemother., 14th, 1985, 1, 28, (synth, pharmacol)
• Kunimoto, T. et al., Cancer Res., 1987, 47, 5944, (pharmacol)
• Koike, K. et al., Gen. Pharmacol., 1989, 20, 763, (pharmacol)
• Kaneda, N. et al., Cancer Res., 1990, 50, 1715, (metab)
• Sawada, S. et al., Chem. Pharm. Bull., 1991, 39, 1446, (synth, trihydrate, pmr, uv, cmr, cryst struct, activity)
• Atsumi, R. et al., Xenobiotica, 1991, 21, 1159, (metab)
• Aiyama, R. et al., Chem. Pharm. Bull., 1992, 40, 2810, (uv, cd, bibl)
• Burris, H.A. et al., Semin. Oncol., 1992, 19, 663, (use, rev)
• Rivory, L.P. et al., Cancer Res., 1994, 54, 6330, (metab, human)
• Curran, D.P. et al., Angew. Chem., Int. Ed., 1995, 34, 2683, (synth)
• Wiseman, L.R. et al., Drugs, 1996, 52, 606, (rev)