Gemcitabine

• 产品号: Bio-0047
• CAS号: 95058-81-4
• 分子式: C9H11F2N3O4
• 分子量: 263.1981464

产品别名

• 标题: Gemcitabine
• IUPAC标准名: 4-amino-1-[(4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
• IUPAC传统名: 4-amino-1-[(4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
• 别名: Gemzar

产品登记号

• CAS号: 95058-81-4

产品性质

• 应用领域: Antineoplastic agent
• 应用领域: Antiviral agent
• 应用领域: Antimetabolite
• 应用领域: Antineoplastic agent for treatment of lung and pancreatic tumours
• 应用领域: Nucleoside transporter substrate
• 生物活性机理: Nucleoside antimetabolite

参考文献

• Hertel, L.W. et al., J.O.C., 1988, 53, 2406, (synth, pmr, cmr)
• Plunkett, W. et al., Nucleosides Nucleotides, 1988, 8, 775, (rev)
• Baker, C.H. et al., J. Med. Chem., 1991, 34, 1879, (pharmacol)
• Chou, T.S. et al., Synthesis, 1992, 565, (synth, ir, uv, cmr, bibl)
• Lund, B. et al., Cancer Treat. Rev., 1993, 19, 45, (use, rev)
• Huang, P. et al., Cancer Chemother. Pharmacol., 1995, 36, 181, (pharmacol)
• Freeman, K.B. et al., J. Chromatogr., B: Biomed. Appl., 1995, 665, 171, (hplc)
• Kawai, M. et al., Xenobiotica, 1995, 25, 405, (metab, rat, dog)
• Guchelaar, H.-J. et al., Cancer Treat. Rev., 1996, 22, 15, (rev)
• Noble, S. et al., Drugs, 1997, 54, 447-472, (rev)
• Burke, T. et al., J. Pharmacol. Exp. Ther., 1998, 286, 1333-1340, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 538