Fluticasone Propionate

• 产品号: Bio-0042
• CAS号: 80474-14-2
• 分子式: C25H31F3O5S
• 分子量: 500.5708496

产品别名

• 标题: Fluticasone Propionate
• IUPAC标准名: (1R,2S,8S,13R,14R,15S,17S)-1,8-difluoro-14-{[(fluoromethyl)sulfanyl]carbonyl}-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-dien-14-yl propanoate
• IUPAC传统名: (1R,2S,8S,13R,14R,15S,17S)-1,8-difluoro-14-{[(fluoromethyl)sulfanyl]carbonyl}-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-dien-14-yl propanoate

产品登记号

• CAS号: 80474-14-2

产品性质

• 应用领域: Corticosteroid
• 应用领域: Antiinflammatory agent
• 应用领域: Used for treatment of inflammatory bowel disease, asthma and allergic rhinitis
• 生物活性机理: Inhibitor of multiple cell types (e.g., mast cells, eosinophils, basophils, lymphocytes, macrophages, and neutrophils) and
• 生物活性机理: mediate production or secretion (e.g., histamine, eicosanoids, leukotrienes, and cytokines)

参考文献

• U.S. Pat., 1982, Synthelabo, 4 315 007; CA, 96, 162737e, (synth)
• Allen, J., J. Labelled Compd. Radiopharm., 1983, 20, 1283, (synth)
• Scott, M.G. et al., Eur. J. Clin. Pharmacol., 1989, 37, 53, (pharmacokinet)
• Rouchouse, A. et al., J. Chromatogr., 1990, 506, 601, (hplc, enantiomers)
• Lefevre-Borg, F. et al., Br. J. Pharmacol., 1993, 109, 1282, (pharmacol)
• Wilde, M.I. et al., Drugs, 1993, 45, 410, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 342