Famciclovir

• 产品号: Bio-0039
• CAS号: 104227-87-4
• 分子式: C14H19N5O4
• 分子量: 321.33176

产品别名

• 标题: Famciclovir
• IUPAC标准名: 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate
• IUPAC传统名: 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate
• 别名: Famvir

产品登记号

• CAS号: 104227-87-4

产品性质

• 应用领域: Antiviral drug
• 应用领域: Used for the treatment of various herpes virus infections, most commonly for herpes zoster (shingles).
• 生物活性机理: Guanine analogue
• 生物活性机理: Prodrug of penciclovir with improved oral bioavailability
• 生物活性机理: Undergoes rapid biotransformation to penciclovir
• 生物活性机理: In cells infected with HSV-1, HSV-2 or VZV, viral thymidine kinase phosphorylates penciclovir to a monophosphate form
• 生物活性机理: that, in turn, is converted to penciclovir triphosphate by cellular (human) kinases
• 生物活性机理: Penciclovir triphosphate selectively inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate
• 生物活性机理: Consequently, herpes viral DNA synthesis and replication are selectively inhibited.

参考文献

• Eur. Pat., 1986, Beecham, 182 024; CA, 105, 133669, (synth, pmr, pharmacol)
• Vere Hodge, R.A. et al., Antimicrob. Agents Chemother., 1989, 33, 1765, (synth, pharmacokinet)
• Genn, G.R. et al., J. Med. Chem., 1989, 32, 1738, (synth)
• Winton, C.F. et al., Anal. Proc. (London), 1990, 27, 181, (hplc)
• Harnden, M.R. et al., Nucleosides Nucleotides, 1990, 9, 499, (cryst struct)
• Vere Hodge, R.A., Antiviral Chem. Chemother., 1993, 4, 67, (rev)
• Sutton, D. et al., Antiviral Res., 1993, 4, 37, (rev)
• Vere Hodge, R.A. et al., Chirality, 1993, 5, 577, (metab)
• Filer, C.W. et al., Xenobiotica, 1994, 24, 357, (metab, pharmacokinet, human)
• Cirelli, R. et al., Antiviral Res., 1996, 29, 141, (rev, pharmacol)
• Brand, B. et al., Tetrahedron, 1999, 55, 5239-5252, (synth, pmr, cmr)
• Freer, R. et al., Tetrahedron, 2000, 56, 4589-4595, (synth, pmr, cmr)