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Suramin

产品号 DB04786 公司名称 DrugBank
CAS号 145-63-1 公司网站 http://www.ualberta.ca/
分子式 C51H40N6O23S6 电 话 (780) 492-3111
分子量 1297.2797 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 4332

产品价格信息

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产品别名

标题
Suramin
IUPAC标准名
8-{4-methyl-3-[3-({[3-({2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzamido]benzamido}naphthalene-1,3,5-trisulfonic acid
IUPAC传统名
8-{4-methyl-3-[3-({[3-({2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzamido]benzamido}naphthalene-1,3,5-trisulfonic acid
商标名
Naganil
Germanin
Naganol
Antrypol
Fourneau
Farma
Belganyl
Moranyl
Naganin
Naphuride
Naganine
别名
Suramine
Bayer 205
Sodium suramin
Suramin sodium
Suramine sodium
SVR

产品登记号

PubChem SID 46507013
PubChem CID 5361
CAS号 145-63-1

产品性质

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. Suramin is manufactured by Bayer in Germany as Germanin?.
Indication For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.
Affected Organisms
Yeast, Molds, Trypanosomes
Biotransformation Little or no metabolism
Absorption Poorly absorbed from the gastrointestinal tract.
Half Life Approximately 36 to 60 days
Protein Binding Approximately 99.7%
External Links
Wikipedia

参考文献