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Benzthiazide

产品号 DB00562 公司名称 DrugBank
CAS号 91-33-8 公司网站 http://www.ualberta.ca/
分子式 C15H14ClN3O4S3 电 话 (780) 492-3111
分子量 431.93736 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 444

产品价格信息

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产品别名

标题
Benzthiazide
IUPAC标准名
3-[(benzylsulfanyl)methyl]-6-chloro-1,1-dioxo-4H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
IUPAC传统名
regulon
商标名
Naclex
Exna
Exosalt
Fovane
Aquatag
Benzothiazide
Benzthazide
Dihydrex
Edemex
Freeuril
Hydrine
Lemazide
Pfizer 1393
Proaqua
Urese
Diucen

产品登记号

PubChem CID 2343
PubChem SID 46506752
CAS号 91-33-8

产品性质

疏水性(logP) 1.7
溶解度 8.91 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Indication For the treatment of high blood pressure and management of edema.
Pharmacology Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Toxicity Symptoms of overdose include nausea, vomiting, fatigue, urinary problems and drowsiness.
Affected Organisms
Humans and other mammals
Absorption Absorbed in the digestive tract.
Protein Binding 30%

参考文献