Cycloleucine

• 产品号: DB04620
• CAS号: 52-52-8
• 分子式: C6H11NO2
• 分子量: 129.15704

产品别名

• 标题: Cycloleucine
• IUPAC标准名: 1-aminocyclopentane-1-carboxylic acid
• IUPAC传统名: cycloleucine
• 别名: ACP; 1-Amino-1-cyclopentanecarboxylic acid; 1-Aminocyclopentanecarboxylate; Amino-1-cyclopentanecarboxylic acid; 1-Aminocyclopentanecarboxylic acid; Cyclo-leucine; Cycloleucin; 1-Amino-cyclopentanecarboxylic acid; 1-Aminocyclopentane-1-carboxylic acid; ACPC

产品登记号

• PubChem SID: 46505671
• PubChem CID: 2901
• CAS号: 52-52-8

产品性质

• 疏水性(logP): -2.28 [TSAI,RS ET AL. (1991)]
• 溶解度: 50 mg/mL at 25 oC [MERCK INDEX (1996)]

产品详细信息

详细说明 (English)

• Drug Groups: experimental
• Description: Cycloleucine is an amino acid formed by cyclization of leucine. Cycloleucine is a non-metabolisable amino acid and is a specific and reversible inhibitor of nucleic acid methylation, and as such is widely used in biochemical experiments. [Wikipedia]
• Pharmacology: Cycloleucine has cytostatic, immunosuppressive and antineoplastic activities.
• Toxicity: Oral, mouse: LD₅₀ = 309 mg/kg; oral, rat: LD₅₀ = 290 mg/kg
• Affected Organisms: Humans and other mammals
• References: Herberg LJ, Rose IC: Effects of D-cycloserine and cycloleucine, ligands for the NMDA-associated strychnine-insensitive glycine site, on brain-stimulation reward and spontaneous locomotion. Pharmacol Biochem Behav. 1990 Aug;36(4):735-8. [Pubmed]
• External Links: Wikipedia

参考文献

• Herberg LJ, Rose IC: Effects of D-cycloserine and cycloleucine, ligands for the NMDA-associated strychnine-insensitive glycine site, on brain-stimulation reward and spontaneous locomotion. Pharmacol Biochem Behav. 1990 Aug;36(4):735-8. Pubmed